The present experiments were designed to investigate the effects of BangPoongSan on the cardiovascular system in the experimental Animals. And thus the change of blood pressure, auricular blood flow, artery contraction, death rate, platelet aggregation repression, plasma coagulation factor activity, plasma antithrombin activity, whole blood viscosity and plasma viscosity were studied.
The result were summarized as the followings:
1. BangPoongSan dropped the blood pressure in the spontaneous hypertensive rat.
2. The drug increased the auricular blood flow in rabbit.
3. The drug relaxed the artery contraction by pretreated norepinephrine in white rat.
4. The drug inhibited the death rate of mouse which was led to thromboembolism by serotonin and collagen.
5. The drug inhibited the platelet aggregation in rat.
6. The drug prolonged the prothrombin time and activated partial thromboplastin time on the test of plasma coagulation factor activity in rat, but was not valuable.
7. The drug presented the antithrombin activity in rat.
8. The drug reduced the whole blood viscosity and plasma viscosity in rat, but the latter was not valuable.
According to the results, Bangpoongsan increased the blood flow and dropped the blood pressure by dilatation of blood vessel smooth muscle. And the drug presented the antithrombin acivity, inhibited the platelet aggregation and reduced blood viscosity. Therefore these effects are assumed to improve the cardiovascular circulation disorder and prevent thrombosis.
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